Inside Out: Bone Marrow Necrosis and Fat Embolism Complicating Sickle-β+ Thalassemia
نویسندگان
چکیده
منابع مشابه
Bone marrow necrosis and fat embolism syndrome: a dreadful complication of hemoglobin sickle cell disease
Sickle cell disease encompasses a wide range of genotypic presentation with particular clinical features. The entity affects millions of people, particularly those whose ancestors came from sub-Saharan Africa and other countries in the Western Hemisphere, Saudi Arabia, and India. Currently, the high frequency of S and C genes reflects natural selection through the protection of heterozygotes ag...
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Manifestations of acute B19 virus infection in sickle cell disease range from transient and benign isolated anemia to life-threatening conditions. We report a case of a B19 virus-induced massive bone marrow necrosis with severe pancytopenia complicated by a fatal secondary acquired fungal superinfection. A 29-year old woman was admitted to hospital for dizziness, muscular and diffuse bone pain,...
متن کاملBone Marrow Necrosis: Frequency and clinicopathilogical Findings in Marrow Biopsyes
Background and Objectives: Bone marrow necrosis (BMN) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. This study was performed to identify frequency and the underlying associated diseases of marrow necrosis. Materials and Methods: In this descriptive study, totally 850 bone marrow trephine biopsies related to living patients at the Pathology ...
متن کاملBone marrow necrosis – initial presentation in sickle cell anemia
PATIENT Male, 20 FINAL DIAGNOSIS: Sickle cell anemia Symptoms: Bone marrow necrosis • bone pain • fever • hepatomegaly • icterus • splenomegaly • weakness MEDICATION - Clinical Procedure: - Specialty: Hematology. OBJECTIVE Unusual clinical course. BACKGROUND In sickle cell disease, bone involvement is the commonest clinical presentation in the acute as well as chronic setting presenting a...
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We describe outcomes after human leukocyte antigen-matched sibling bone marrow transplantation (BMT) for 179 patients with β-thalassemia major. The median age at transplantation was 7 years and the median follow-up was 6 years. The distribution of Pesaro risk class I, II, and III categories was 2%, 42%, and 36%, respectively. The day 30 cumulative incidence of neutrophil recovery and day 100 pl...
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ژورنال
عنوان ژورنال: The American Journal of Medicine
سال: 2016
ISSN: 0002-9343
DOI: 10.1016/j.amjmed.2016.05.027